Carly/Ava: Carly (Laura Wright) and Ava (Maura West) get into a nasty argument that turns into a catfight!
Nik/Robin/Patrick: Nikolas (Tyler Christopher) stresses how important it is for Robin (Kimberly McCullough) not to be seen in Port Charles. She puts on a costume, and heads to the hospital Halloween party.
Before the party, Patrick (Jason Thompson) and Epiphany (Sonya Eddy) have a long chat about Robin.
Sabrina/Carlos: Carlos (Jeffrey Vincent Parise) vows to do whatever he can to break up Sabrina's (Teresa Castillo) engagement.
Alexis: Alexis (Nancy Lee Grahn) keeps being drawn to shady men! How will she react when she learns the true identity of Derek (William deVry) Wells?
Sam/Silas/Delia: Delia (Ilene Kristen) gives Sam (Kelly Monaco) and Silas (Michael Easton) intel on the twisted Jerome family tree. Should Ava (Maura West) be planning a trip home for Mother's Day?
Morgan/Derek: Morgan (Brian Craig) aligns himself with Sonny's (Maurice Benard) enemies. Will he really be able to side against his father in a bloody mob war?
Olivia/Sonny: Olivia (Lisa LoCicero) considers telling Dante (Dominic Zamprogna) about Sonny’s theory on Derek being Julian Jerome.
Elle/Spinelli: Ellie (Emily Wilson) bears her soul to Spinelli (Bradford Anderson) about their relationship. She demands to know where they stand.
Artistic License: Franco's (Roger Howarth) lies about who painted his new collection will cause problems for Carly (Laura Wright). Look for the budding couple to also get pulled into the Jerome/Corinthos mob war.
Duke to the rescue: Duke (Ian Buchanan) sets out to find Anna (Finola Hughes).
Hospital Halloween Party: General Hospital hosts a huge Halloween Costume Party. It is a two-day episode full of several surprises.